The use of primitives in the calculation of radiative view factors

Compilations of radiative view factors (often in closed analytical form) are readily available in the open literature for commonly encountered geometries. For more complex three-dimensional (3D) scenarios, however, the effort required to solve the requisite multi-dimensional integrations needed to estimate a required view factor can be daunting to say the least. In such cases, a combination of finite element methods (where the geometry in question is sub-divided into a large number of uniform, often triangular, elements) and Monte Carlo Ray Tracing (MC-RT) has been developed, although frequently the software implementation is suitable only for a limited set of geometrical scenarios. Driven initially by a need to calculate the radiative heat transfer occurring within an operational fibre-drawing furnace, this research set out to examine options whereby MC-RT could be used to cost-effectively calculate any generic 3D radiative view factor using current vectorisation technologies

2016-2017 Master Class - Eugene Izotov (Oboe)

https://spiral.lynn.edu/conservatory_masterclasses/1010/thumbnail.jp

2015-2016 Master Class - Nancy Ambrose King (Oboe)

https://spiral.lynn.edu/conservatory_masterclasses/1012/thumbnail.jp

The Suppression of Star Formation and the Effect of Galaxy Environment in Low-Redshift Galaxy Groups

Understanding the interaction between galaxies and their surroundings is central to building a coherent picture of galaxy evolution. Here we use GALEX imaging of a statistically representative sample of 23 galaxy groups at z=0.06 to explore how local and global group environment affect the UV properties and dust-corrected star formation rates of their member galaxies. The data provide star formation rates out to beyond 2R_200 in all groups, down to a completeness limit and limiting galaxy stellar mass of 0.06 M_sun/yr and 10^8 M_sun, respectively. At fixed galaxy stellar mass, we find that the fraction of star-forming group members is suppressed relative to the field out to an average radius of R ~ 1.5 Mpc ~ 2R_200, mirroring results for massive clusters. For the first time we also report a similar suppression of the specific star formation rate within such galaxies, on average by 40% relative to the field, thus directly revealing the impact of the group environment in quenching star formation within infalling galaxies. At fixed galaxy density and stellar mass, this suppression is stronger in more massive groups, implying that both local and global group environment play a role in quenching. The results favor an average quenching timescale of at least ~2 Gyr and strongly suggest that a combination of tidal interactions and starvation is responsible. Despite their past and ongoing quenching, galaxy groups with more than four members still account for at least ~25% of the total UV output in the nearby universe.Comment: 15 pages, 13 figures. ApJ accepte

2015-2016 Music for the Mind

https://spiral.lynn.edu/conservatory_otherseasonalconcerts/1004/thumbnail.jp

The Vehicle, Fall 2003

Table of Contents Blame It on My BirthsignMichael Doizanpage 4 Like a BanjoKaitlyn Kingstonpage 6 A BubbleMaria Santoyopage 7 UntitledLiz Toyntonpage 8 She Said It Was Stuck in the FenceGreg Holdenpage 11 Thanksgiving Table CharactersKrystal Heringpage 12 This Is My LandKorah Winnpage 13 Bleeding HeartsKaitlyn Kingstonpage 14 SoldierEmily Rapppage 17 HomelessLaTasha Harrispage 18 InfinitiLindsey Nawojskipage 19 Gone Until ForeverAndy Whytepage 20 On My WayKristin Bornpage 27 GloryJay Popepage 28 Untitled (1)Trevor Moorepage 29 Nature\u27s MoratoriumMatt McCarthypage 29 Untitled (2)Trevor Moorepage 30 Eternal ChildAmy Towerypage 31 FingersJosh Sopiarzpage 31 She Likes JazzMario Podeschipage 32 Back Alley FarmsScott E. Lutzpage 33 Biographiespage 35https://thekeep.eiu.edu/vehicle/1078/thumbnail.jp

Cerebral blood volume, genotype and chemosensitivity in oligodendroglial tumours

INTRODUCTION: The biological factors responsible for differential chemoresponsiveness in oligodendroglial tumours with or without the −1p/−19q genotype are unknown, but tumour vascularity may contribute. We aimed to determine whether dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) could distinguish molecular subtypes of oligodendroglial tumour, and examined the relationship between relative cerebral blood volume (rCBV) and outcome following procarbazine, lomustine and vincristine (PCV) chemotherapy. METHODS: Pretherapy rCBV was calculated and inter- and intraobserver variability assessed. Allelic imbalance in 1p36, 19q13, 17p13, 10p12–15, and 10q22–26 and p53 mutation (exons 5–8) were determined. rCBV was compared with genotype and clinicopathological characteristics (n=37) and outcome following PCV chemotherapy (n=33). RESULTS: 1p/19q loss was seen in 6/9 grade II oligodendrogliomas, 6/14 grade II oligoastrocytomas, 4/4 grade III oligodendrogliomas, and 3/10 grade III oligoastrocytomas. rCBV measurements had good inter- and intraobserver variability, but did not distinguish histology subtype or grade. Tumours with 1p/19q loss had higher rCBV values (Student’s t-test P=0.001). Receiver operating characteristic analysis revealed a cut-off of 1.59 for identifying genotype (sensitivity 92%, specificity 76%). Tumours with high and low rCBV showed response to chemotherapy. The −1p/−19q genotype, but not rCBV, was strongly associated with response, progression-free and overall survival following PCV chemotherapy. Tumours with high rCBV and intact 1p/19q were associated with shorter progression-free and overall patient survival than those with intact 1p/19q and low rCBV or high rCBV and 1p/19q loss. CONCLUSION: rCBV identifies oligodendroglial tumours with 1p/19q loss, but does not predict chemosensitivity. The prognostic significance of rCBV may differ in oligodendroglial tumours with or without the −1p/−19q genotype

2020 Collage Concert

An exciting highlight each season, Collage is the signature production of the School of Music and a major fundraising event for supporting scholarships for music students. This special performance features over 200 student and faculty performers and includes jazz, orchestra, choir, band, percussion, and opera selections for soloists, chamber groups, and ensembles. Special lighting effects and stage design combine with the diverse and exciting program presented as rapid-fire, flowing vignettes to create a truly unique performance.https://digitalcommons.kennesaw.edu/musicprograms/2295/thumbnail.jp

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

TDP2 is a 5’-tyrosyl DNA phosphodiesterase important for the repair of DNA adducts generated by non-productive (abortive) activity of topoisomerase II. TDP2 facilitates therapeutic resistance to topoisomerase poisons, which are widely used in the treatment of a range of cancer types. Consequently, TDP2 is an interesting target for the development of small molecule inhibitors that could restore sensitivity to topoisomerase-directed therapies. Previous studies identified a class of deazaflavin-based molecules that showed inhibitory activity against TDP2 at therapeutically useful concentrations, but their mode of action was uncertain. We have confirmed that the deazaflavin series inhibits TDP2 enzyme activity in a fluorescence-based assay, suitable for HTS-screening. We have gone on to determine crystal structures of these compounds bound to a ‘humanised’ form of murine TDP2. The structures reveal their novel mode of action as competitive ligands for the binding site of an incoming DNA substrate, and point the way to generating novel and potent inhibitors of TDP2